When Should Injection Be Repeated or Escalated?

What happens if a Morton’s neuroma injection does not work?

Short answer: A limited response should prompt review of the diagnosis, injection accuracy, footwear, mechanics and competing pathology before simply repeating treatment.

A second injection may be reasonable in selected circumstances, particularly after meaningful but incomplete benefit. Repeated steroid injections should not become an indefinite pathway because cumulative tissue risks matter.

When pain remains limiting, ultrasound-guided hydrodissection or surgery may be considered. Escalation is based on function and patient priorities, not neuroma size alone.